Plant Transcription Factor Database
Previous version: v3.0
Arachis hypogaea
HD-ZIP Family
Species TF ID Description
Ahy015341HD-ZIP family protein
Ahy019998HD-ZIP family protein
Ahy020068HD-ZIP family protein
Ahy018737HD-ZIP family protein
Ahy008909HD-ZIP family protein
Ahy001264HD-ZIP family protein
Ahy008979HD-ZIP family protein
Ahy018000HD-ZIP family protein
Ahy001270HD-ZIP family protein
Ahy008705HD-ZIP family protein
Ahy000160HD-ZIP family protein
Ahy016384HD-ZIP family protein
Ahy010677HD-ZIP family protein
Ahy020847HD-ZIP family protein
Ahy012088HD-ZIP family protein
Ahy014224HD-ZIP family protein
Ahy018844HD-ZIP family protein
Ahy018914HD-ZIP family protein
Ahy010302HD-ZIP family protein
Ahy013432HD-ZIP family protein
Ahy019042HD-ZIP family protein
Ahy012126HD-ZIP family protein
Ahy013621HD-ZIP family protein
Ahy010176HD-ZIP family protein
Ahy017300HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401